![]() Recently, several polymorphic traits of different genes involved with 5-FU biotransformation have been reported. Some adverse drug responses can be predicted by pharmacogenomics. Unfortunately, in some patients, 5-FU is toxic and causes gastrointestinal and hematologic lesions leading to the suspension of therapy. ![]() In particular, 5-fluorouracil (5-FU) is the backbone of several chemotherapic protocols for treatment of solid tumors. Genetic testing of drug response represents an important goal for targeted therapy. However, the evolution in technology should allow application of the techniques as a tool in toxicology laboratories and thus more widespread exploitation of their potential. Currently the techniques are in the hands of specialists, principally in academic institutes. This paper is an overview of sample clean-up, chromatographic separation and mass spectrometry detection procedures which can be combined to obtain screening methods adapted to the constraints and needs of various laboratories, and none specifically in clinical toxicology. ![]() For these reasons, an increasing number of applications for multi-target screening or general screening of unknown compounds in biological matrices are being published. The high selectivity and sensitivity of liquid chromatography coupled to mass spectrometry or tandem mass spectrometry technology provides an attractive alternative to the current methods. The screening of a wide range of toxicologically relevant compounds in biological samples is a serious challenge for clinical laboratories. ![]() Toxicological screening is the analysis of a biological specimen to detect and identify compounds in patients admitted to the hospital with acute intoxication of unknown origin. ![]()
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